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The use of celecoxib in patients 2 years to 17 years of age with celebrex non prescription delivery pauciarticular, polyarticular course JRA or day in patients with systemic onset JRA was studied in a day 12-week, double-blind, active controlled, celebrex non prescription pharmacokinetic, safety and efficacy study, with a 12-week open-label extension. Poor Metabolizers Of CYP2C9 Substrates In patients who celebrex are known or suspected to be poor CYP2C9 metabolizers (i.e., CYP2C9*3 3 based next on genotype or previous history/experience with other CYP2C9 substrates (such as warfarin, phenytoin ) administer celebrex starting with half the lowest recommended dose. Nsaids, including Celebrex, may increase the risk of bleeding events. Intervention: During concomitant use of celebrex and lithium, monitor patients for signs of lithium toxicity. Small studies in women treated with nsaids have also day shown a reversible delay in ovulation. The long-term cardiovascular toxicity in children exposed to celebrex has not been evaluated and it is unknown if the long-term risk may be similar to that seen in adults exposed to celebrex or other COX-2 selective delivery and non-selective nsaids (see boxed warning, delivery warnings AND precautions. The most commonly occurring (5) adverse events in celecoxib treated patients were headache, fever (pyrexia upper abdominal pain, cough, nasopharyngitis, abdominal pain, nausea, arthralgia, diarrhea and vomiting. The concurrent use of aspirin and an nsaid, such as celecoxib, increases the risk of serious gastrointestinal (GI) events see Warnings and Precautions (5.2). Risk Factors For GI Bleeding, Ulceration, And Perforation Patients with a prior history of peptic ulcer disease and/or GI bleeding who used nsaids had a greater than 10-fold increased risk for developing a GI bleed compared next to patients without these risk factors. More than 8,500 patients received a total daily next dose of celebrex of 200 mg (100 mg twice daily or 200 mg once daily) or more, including more than 400 treated at 800 mg (400 mg twice daily). Among next subjects with RA,.7 (453/813) escalated celecoxib to the 200 mg twice daily dose,.5 (470/832) escalated ibuprofen to 800 mg three times daily, and.6 (432/791) escalated naproxen to the 500 mg twice daily dose; however. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Specific Populations Geriatric At steady state, elderly subjects (over 65 years old) had a 40 higher Cmax and a 50 higher AUC compared to the young subjects.

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